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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
21.82
Human Site:
Y677
Identified Species:
48
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
Y677
L
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
Y678
S
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
Y646
V
L
E
F
D
Y
E
Y
T
E
T
G
E
R
L
Dog
Lupus familis
XP_533420
1645
181128
Y948
S
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
Y684
S
L
E
Y
D
Y
E
Y
D
E
N
G
D
R
V
Rat
Rattus norvegicus
XP_001073260
1338
150427
H648
S
L
E
Y
D
Y
E
H
D
E
N
G
D
R
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
F618
G
S
F
S
E
N
G
F
I
K
I
F
M
E
Q
Chicken
Gallus gallus
XP_419725
1260
143069
K619
I
A
L
H
K
H
L
K
H
K
N
I
V
Q
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
Y666
A
L
E
Y
D
Y
E
Y
D
E
H
G
E
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
K619
A
I
K
E
V
P
E
K
N
S
Q
D
V
Q
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
S638
H
E
E
I
L
L
H
S
R
L
S
H
K
N
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
93.3
60
93.3
N.A.
93.3
86.6
N.A.
0
6.6
N.A.
73.3
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
93.3
86.6
93.3
N.A.
93.3
93.3
N.A.
20
40
N.A.
93.3
N.A.
33.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
64
0
0
0
55
0
0
10
46
0
0
% D
% Glu:
0
10
73
10
10
0
73
0
0
64
0
0
19
10
0
% E
% Phe:
0
0
10
10
0
0
0
10
0
0
0
10
0
0
0
% F
% Gly:
10
0
0
0
0
0
10
0
0
0
0
64
0
0
0
% G
% His:
10
0
0
10
0
10
10
10
10
0
10
10
0
0
0
% H
% Ile:
10
10
0
10
0
0
0
0
10
0
10
10
0
0
10
% I
% Lys:
0
0
10
0
10
0
0
19
0
19
0
0
10
10
0
% K
% Leu:
10
64
10
0
10
10
10
0
0
10
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
10
0
55
0
0
10
0
% N
% Pro:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
19
10
% Q
% Arg:
0
0
0
0
0
0
0
0
10
0
0
0
0
55
0
% R
% Ser:
37
10
0
10
0
0
0
10
0
10
10
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% T
% Val:
10
0
0
0
10
0
0
0
0
0
0
0
19
0
55
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
55
0
64
0
55
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _